Università degli Studi di Parma
Dipartimento Farmaceutico

Laboratory of Permeation, Transdermal Systems and Iontophoresis

• In vitro permeation of bevacizumab through human sclera: effect of iontophoresis application, S. Pescina, G. Ferrari, P. Govoni, C. Macaluso, C. Padula, P. Santi, S. Nicoli, J. Pharm. Pharmacol., 2010
• Single Layer Transdermal Film Containing Lidocaine: Water and Lidocaine Mobility Determined using Neutron Scattering, C. Padula, C. Chiapponi, M.T. Dibari, A. Deriu, F. Sonico, S. Barbieri, J. Ollivier, P. Santi, J. Pharm. Sci., 2010
• Bioadhesive films containing benzocaine: correlation between in vitro permeation and in vivo local anesthetic effect, D. R. de Araujo, C. Padula, C. M. S. Cereda, G. R. Tófoli, R. Barbosa Brito Júnior, E. de Paula, S. Nicoli, P. Santi, Pharm. Res., 2010
  
• Stratum corneum distribution of lidocaine in vivo from a new bioadhesive transdermal film, C. Padula, A. Fulgoni, P. Santi, Skin Res. and Technol., 16, 125-130 (2010).
• Development and evaluation of occlusive systems employing polyvinyl alcohol for transdermal delivery of sumatriptan succinate, C. Balaguer-Fernández, C. Padula, A. Femenía-Font, V. Merino, P. Santi, A. López-Castellano, Drug Delivery, 17 (2), 83-91 (2010).
• Lecithin/chitosan nanoparticles of clobetasol-17-propionate capable of accumulation in pig skin, T. Senyigit, F. Sonvico, S. Barbieri, O. Ozer, P. Santi. P. Colombo, J. Control. Release, 142, 368-373 (2010).
• Effect of lipopeptides and iontophoresis on acyclovir skin delivery, S. Nicoli, M. Eeman, M. Degeu, E. Bresciani, C. Padula, P. Santi, J. Pharm. Pharmacol., 62, 702-708 (2010)
  

• Different approaches for improving skin accumulation of topical corticosteroids, T. Senyigit, C. Padula, O. Ozer, P. Santi, Int. J. Pharm., 380, 155-160 (2009)
• In-vitro transcleral iontophoresis of high molecular weight neutral compounds, S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Santi, Eur. J. Pharm. Sci., 36, 486-492 (2009).
• Porcine sclera as a model for human sclera in in vitro transport experiments: histology, sem microscopy and comparative permeability, S. Nicoli, G. Ferrari, M. Quarta, C. Macaluso, P. Govoni, D. Dallatana, P. Santi, Molecular Vision, 15, 259-266 (2009).
• Synthesis, hydrolysis and skin retention of aminoacid esters of a-tocopherol, F. Marra, C. Ostacolo, S. Laneri, A. Bernardi, A. Sacchi, C. Padula, S. Nicoli, P. Santi, J. Pharm. Sci., 98 (7), 2364-2376 (2009)
• Innovative formulations for the delivery of levothyroxine to the skin, C. Padula, S. Nicoli, P. Santi, Int. J. Pharm., 372, 12-16 (2009).

• Association of nicotinamide with parabens: effect on solubilità, partition and transdermal permeation, S. Nicoli, F. Zani, S. Bilzi, R. Bettini, P. Santi, Eur J. Pharm. Bipharm., 69, 613-621 (2008)
  
• In vitro evaluation of the effect of electrotreatment on skin permeability, F. Marra, J.L. Levy, P. Santi, Y. Kalia, Journal of Cosmetic Dermatol., 7, 105-111 (2008)
• Characterization of rabbit ear skin as a skin model for in vitro transdermal permeation experiments: histology, lipid composition and permeability, S. Nicoli, C. Padula, V. Aversa, B. Vietti, P.W. Wertz, A. Millet, F. Falson, P. Govoni, P. Santi, Skin Pharmacol. and Physiol, 21, 218-226 (2008)
• Ethyl-paraben and nicotinamide mixtures: apparent solubility, thermal behaviour and X-ray structure of the 1:1 co-crystal, S. Nicoli, S. Bilzi, P. Santi, M.R. Caira, J. Li, R. Bettini, J. Pharm. Sci., 97 (11), 4830-4839 (2008).
  
• Physical characterization of a new skin bioadhesive film, A. Nussinovitch, A. Gal, C. Padula, P. Santi, AAPS Pharm. Sci. Tech., 9 (2), 458-463 (2008).
  
• Simultaneous determination of benzophenone-3, retinol and retinyl acetate in ear pig skin layers by high-performance liquid chromatography, C. Padula, N. Campana, P. Santi, Biomed Chromatog., 22, 1060-1065 (2008)
• Transdermal Film Containing Nicotine and Bupropion for Combined Smoking Cessation Therapy, S. Nicoli, S. Cella, V. Aversa, P. Santi, Pharmaceutical Technology Europe, 20 (2), 22-29
  
• Characterization of rabbit ear skin as a skin model for in vitro transdermal permeation experiments: histology, lipid composition and permeability, S. Nicoli, C. Padula, V. Aversa, B. Vietti, P.W. Wertz, A. Millet, F. Falson, P. Govoni, P. Santi, Skin Pharmacol. and Physiol, 21, 218-226 (2008)
• In vitro evaluation of the effect of electrotreatment on skin permeability, F. Marra, J.L. Levy, P. Santi, Y. Kalia, Journal of Cosmetic Dermatol., 7, 105-111 (2008)
• Association of nicotinamide with parabens: effect on solubilità, partition and transdermal permeation, S. Nicoli, F. Zani, S. Bilzi, R. Bettini, P. Santi, Eur J. Pharm. Bipharm., 69, 613-621 (2008)
• In vitro permeation of levothyroxine across the skin, C. Padula, A. Pappani, P. Santi, Int. J. Pharm., 349, 161-165 (2008)

• In vitro skin permeation and retention of parabens from cosmetic formulations, S. Pedersen, F. Marra, S. Nicoli, P. Santi, Int. J. Cosmetic Sci., 29, 361-367 (2007).
• Bioadhesive film for dermal and transdermal drug delivery, C. Padula, S. Nicoli, V. Aversa, P. Colombo, F. Falson, F. Pirot, P. Santi, Eur. J. Dermatol., 17 (4), 309-312 (2007)
• Single-layer transdermal film containing lidocaine: modulation of drug release, C. Padula, S. Nicoli, P. Colombo, P. Santi, Eur. J. Pharm. Biopharm.,66 (3), 422-428 (2007)
• Suitability of excised rabbit ear skin - fresh and frozen - for evaluating the transdermal permeation of estradiol, S. Nicoli, P. Santi, Drug Delivery, , 14 (4), 195-199 (2007)

• Tecnologia Patch-non-Patch, S. Nicoli, P. Santi, Kosmetica, 8, 54-56 (2006).
• New transdermal bioadhesive film containing oxybutynin: in vitro permeation across rabbit ear skin, S. Nicoli, E. Penna, C. Padula, P. Colombo, P. Santi, Int. J. Pharm., Int. J. Pharm., 325, 2-7 (2006)
• Bioadhesive mono-layer film for the in vitro transdermal delivery of sumatriptan , A. Femenía-Font, C. Padula, F. Marra, C. Balaguer-Fernández, V. Merino, A. López-Castellano, S. Nicoli, P. Santi, J. Pharm. Sci., 95(7), 1561-1569 (2006)
• Assay of amikacin in the skin by high-performance liquid chromatography, S. Nicoli, P. Santi, Journal of Pharmaceutical and Biomedical Analysis, 41(3), 994-997 (2006)
• Transdermal delivery of aminoglycosides: amikacin transport and iontophoretic non invasive monitoring, S. Nicoli, P. Santi, J. Control. Release, 111 (1-2), 89-94 (2006)
• Assemblage of novel release modules for the development of adaptable drug delivery systems, E. Losi, R. Bettini, P. Santi, F. Sonvico, G. Colombo, K. Lofthus, P. Colombo, N.A. Peppas, J. Control. Release, 111 (1-2), 212-218 (2006)
• The effect of residual water on antacid activity of sucralfate gel dried by microwaves, A. Gainotti, E. Losi, P. Colombo, P. Santi, F. Sonvico, G. Colombo, P. del Gaudio, AAPS Pharm. Sci. Tech., 7 (1) art. 9 (2006)

• The influence of iontophoresis on acyclovir transport and accumulation in rabbit ear skin, C. Padula, F. Sartori, F. Marra, P. Santi, Pharm. Res., 22 (9), 1519-1524 (2005)
• Effect of residual water content on the physico-chemical properties of sucralfate dried gel obtained by microwave drying, A. Gainotti, E. Losi, R. Bettini, P. Colombo, F. Sonvico, D. Baroni, P. Santi, G. Colombo, Drug Dev. Ind. Pharmacy, 31, 645-652 (2005)
• Release and permeation kinetics of caffeine from bioadhesive transdermal films, S. Nicoli, P. Colombo, P. Santi, The AAPS Journal, 7 (1), art 20 (2005)
• Effect of Lactic Acid and Iontophoresis on Drug Permeation Across Rabbit Ear Skin, P. Sebastiani, S. Nicoli, P. Santi, Int. J. Pharm., 192 (1-2), 119-126 (2005)

• The surface roughness of lactose particles can be reduced by wet-smoothing using a high-shear mixer, F. Ferrari, D. Cocconi, R. Bettini, F. Giordano, P. Santi, M. Tobyn, R. Price, P. Young, C. Caramella, P. Colombo, AAPS Pharm Sci Tech, 5 (4) art. 60 (2004)
• Chimerical agglomerates of microparticles for the administration of caffeine nasal powders, P. Russo, F. Buttini, F. Sonvico, R. Bettini, C. Sacchetti, P. Colombo, P. Santi, J. Drug Del. Sci. and Technol., 14 (6), 449-454 (2004)
• Bioadhesive transdermal film containing caffeine, S. Nicoli, V. Amoretti, P. Colombo, P. Santi, Skin Pharmacol. and Physiol., 17 (3), 119-123 (2004)
• Effect of chemical enhancers and iontophoresis on thiocolchicoside permeation across rabbit and human skin in vitro, M. Artusi, S. Nicoli, P. Colombo, R. Bettini, A. Sacchi, P. Santi, J. Pharm. Sci., 93 (10) 2431-2438 (2004)
• Alpha-Tocopherol pro-vitamins: sinthesis, hydrolysis and accumulation in rabbit ear skin, C. Ostacolo, F. Marra, S. Laneri, A. Sacchi, S. Nicoli, C. Padula, P. Santi, J. Control. Release, 99 (3), 403-413 (2004)
  

• Buccal delivery of thiocolchicoside: in vitro and in vivo permeation studies, M. Artusi, P. Santi, P. Colombo, H.E. Junginger, Int. J. Pharm., 250 (1), 203-213 (2003).
• In vitro and in vivo study of 5-methoxypsoralen skin concentration after topical application, G. Colombo, A. Zucchi, F. Allegra, P. Colombo, F. Zani, P. Santi, Skin Pharmacol. Appl. Skin Physiol., 16 (2), 130-136 (2003)
• Skin permeation of 5-methoxypsoralen from topical dosage forms, G. Colombo, M. Artusi, P. Santi, P. Colombo, R. Bettini, A. Zucchi, S. Nicoli, Drug Dev. Ind. Pharm., 29 (2), 247-251 (2003)
• Bioadhesive film for the transdermal delivery of lidocaine: in vitro and in vivo behavior, C. Padula, G. Colombo, S. Nicoli, P.L. Catellani, G. Massimo, P. Santi, J. Control. Release, 88 (2), 277-285 (2003)
• Characterization of the permselective properties of rabbit skin during transdermal iontophoresis, S. Nicoli, M. Cappellazzi, P. Colombo, P. Santi, J. Pharm, Sci., 92 (7), 1482-1488 (2003)
• The suitability of disintegrating force kinetics for studying the effect of manufacturing parameters on spironolactone tablet properties, G. Massimo, P. Santi, G. Colombo, S. Nicoli, F. Zani, P. Colombo, R. Bettini, AAPS PharmSciTech, 4 (2), art. 17 (2003)
• Post-iontophoresis transport of ibuprofen lysine across rabbit ear skin, P. Santi, S. Nicoli, G. Colombo, R. Bettini, M. Artusi, S. Rimondi, C. Padula, P. Rizzo, P. Colombo, Int. J. Pharm, 266, 69-75 (2003).
  

• Influence of layer position on in vitro and in vivo release of levodopa methyl ester and carbidopa from three-layer matrix tablet, R. Bettini, D. Acerbi, G. Caponetti, R. Musa, N. Magi, P. Colombo, D. Cocconi, P. Santi, P.L. Catellani, P. Ventura, Eur J. Pharm. Biopharm., 53 (2), 227-232 (2002).
• Caffeine microparticles for nasal administration obtained by spray drying, C. Sacchetti, M. Artusi, P. Santi, P. Colombo, Int. J. Pharm., 242 (1-2), 335-339 (2002).
• The role of dissolution test in a comparison of generic and branded controlled-release products, R. Bettini, C. Camellini, L. Marzocchi, G. Colombo, P. Santi, S.T.P. Pharma Sci., 12 (3), 167-172 (2002).
• Distribution and quantification of polyethylenimine oligodeoxynucleotide complexes in human skin after iotophoretic delivery using confocal scanning laser microscopy, C. Brus, P. Santi, P. Colombo, T. Kissel, J. Control. Release, 84, 171-181 (2002).
  

• Design of triptorelin loaded nanospheres for transdermal iontophoretic administration, S. Nicoli, P. Santi, P. Couvreur, G. Couarraze, P. Colombo, E. Fattal, Int. J. Pharm., 214, 31-35 (2001)
• Translocation of drug particles in HPMC matrix gel layer: effect of drug solubility and influence on drug release, R. Bettini, P.L. Catellani, P. Santi, G. Massimo, N.A. Peppas, P. Colombo, J. Control. Release, 70 (3), 383-391 (2001)
• Plasma and skin concentration of 5-Methoxypsoralen in psoriatic patients after oral administration, A. Zucchi, E. Raho, B. Marconi, S. Nicoli, M. Santini, F. Allegra, P. Colombo, R. Bettini, P. Santi, J. Invest. Dermatol., 117, 379-382 (2001).
• Physical and chemical enhancement of transdermal delivery of triptorelin, S. Nicoli, S. Rimondi, P. Colombo, P. Santi, Pharm. Res., 18 (11), 1634-1637 (2001).
  

• Influence of flow and packing properties on the pneumatic conveying of powdered mixtures for direct compression, C. D'Andria, G. Massimo, P.L. Catellani, P. Santi, R. Bettini, L. Bianco, P. Colombo, Pharm. Tech. Europe, 1, 17-23 (2000)
• Response surface methodology applied to fluid bed granulation, P. Wherlé, P. Colombo, P. Santi, R. Bettini, F. Cudazzo, A. Nora, C. Tenore, P.L. Catellani, Pharm. Tech. Europe, 12 (4), 36-46 (2000)
• Disintegration propensity of tablets evaluated by means of disintegrating force kinetics, G. Massimo, P.L. Catellani, P. Santi, R. Bettini, G.L. Vaona, A. Bonfanti, L. Maggi, P. Colombo, Pharm. Dev. and Technology, 5 (2), 163-169 (2000)
• Dried sucralfate gel retaining the colloidal properties of sucralfate moist gel, L. Maggi, P.L. Catellani, E. Fisicaro, P. Santi, F. Zani, P. Colombo, AAPS PharmSciTech., 1 (3), art 28 (2000)
  

• Distribution of khellin in excised human skin following iontophoresis and passive dermal transport, B. Marconi, F. Mancini, P. Colombo, F. Allegra, F. Giordano, A. Gazzaniga, G. Orecchia, P. Santi, J. Control. Release, 60 (2-3), 261-268 (1999)
• Ionized prodrugs of dehydroepiandrosterone for transdermal iontophoretic delivery, S. Laneri, A. Sacchi, E. Abignente di Frassello, E. Luraschi, P. Colombo, P. Santi, Pharm. Res., 16 (12), 1818-1824 (1999)
• Drug volume fraction profile in the gel phase and drug release kinetics in hydroxypropylmethil cellulose matrices containing a soluble drug, P. Colombo, R. Bettini, P.L. Catellani, P. Santi, N.A. Peppas, Eur. J. Pharm. Sci., 9 (1), 33-40 (1999)
• Nicotine nasal powder: design and characterization, R. Bettini, C. D'Andria, P.L. Catellani, P. Santi, G. Massimo, P. Colombo, STP Pharma Sciences, 9 (5), 457-462 (1999)
  

• In vitro acyclovir distribution in human skin layers after transdermal iontophoresis, N.M. Volpato, S. Nicoli, C. Laureri, P. Colombo, P. Santi, J. Control. Release, 50 (1-3), 291-296 (1998)
• Partial permselective coating adds an osmotic contribution to drug release from swellable matrixes, P.L. Catellani, P. Colombo, N.A. Peppas, P. Santi, R. Bettini, J. Pharm. Sci., 87 (6), 726-731 (1998)
  

• Drug reservoir composition and transport of salmon calcitonin in transdermal iontophoresis, P. Santi, P. Colombo, R. Bettini, P.L Catellani, A. Minutello, N.M. Volpato, Pharm. Res., 14 (1), 63-66 (1997)
• Clean-In-Place System Evaluation of a Rotary Tabletting Machine, A. Bonfanti, P. Colombo, R. Trebbi, F. Cerveglieri, P. Santi, G. Massimo, P.L. Catellani, Pharmaceutical Technology Europe, 9 (4), 31-38 (1997).
• Evaluation of preservative effectiveness in pharmaceutical products: the use of a wild strain of Pseudomonas cepacia, F. Zani, A. Minutello, L. Maggi, P. Santi, P. Mazza, J. Applied Bacteriology, 83 (3), 322-326 (1997)
• Transdermal iontophoresis of salmon calcitonin can reproduce the hypocalcemic effect of intravenous administration, P. Santi, N.M. Volpato, R. Bettini, P.L. Catellani, G. Massimo, P. Colombo, Il Farmaco, 51 (6-7), 445-448 (1997)
• Assay of acyclovir in human skin layers by high-performance liquid chromatography, N.M. Volpato, P. Santi, C. Laureri, P. Colombo, J. Chrom. Biomed. Appl., 16 (3), 515-520 (1997)
  

• Reverse Iontophoresis - Parameters Determining Electroosmotic flow: I. pH and Ionic Strength, P. Santi and R.H. Guy, J. Contr. Release, 38, 159-165 (1996)
• Delivery of nasal powders of ß-cyclodextrin by insufflation, A. De Ascentiis, R. Bettini, G. Caponetti, P.L. Catellani, M.T. Peracchia, P. Santi, P. Colombo, Pharm. Res., 13 (5), 734-738 (1996)
• Analysis of the swelling and release mechanisms from drug delivery systems with emphasis on drug solubility and water transport, P. Colombo, R. Bettini, P. Santi, A. De Ascentiis, N.A. Peppas, J. Contr. Release, 39, 231-237 (1996)
• Reverse Iontophoresis - Parameters Determining Electroosmotic flow: II. Electrode chamber formulation, P. Santi and R.H. Guy, J. Contr. Relesae,42, 29-36 (1996)
• The suitability of a small scale high-shear mixer for powder pelletization, L. Maggi, A. Bonfanti, P. Santi, G. Massimo, P.L. Catellani, A. Bellotti, P. Colombo, A. Zanchetta, Pharm. Technol. Europe, 8 (9), 82-90 (1996)
  

• Drug diffusion front movement is important in drug release control from swellable matrix tablets, P. Colombo, R. Bettini, G. Massimo, P.L. Catellani, P. Santi, N.A. Peppas, J. Pharm. Sci., 84 (8), 991-997 (1995)
• Iontophoresis enhances the acyclovir transport through nude mouse skin by electrotransport and electroosmosis, N.M. Volpato, P. Santi, P. Colombo, Pharm. Res., 12 (11), 1623-1627 (1995)
• The technology of pharmaceutical powders for nasal administration of drugs with systemic effect, A. De Ascentiis, P. Santi, P. Colombo, BCF International, 134 (0), 18-20 (1995)
  

• Iontophoretic transport of verapamil and melatonin through hairless mouse skin, P. Santi, G. Massimo, P.L. Catellani, G. Morini, P. Colombo, Europ. J. Pharm. Sci., 1, 259-263 (1994)

• Iontophoretic transport of verapamil and melatonin. I. Cellophane membranes as barrier, P. Santi, P.L. Catellani, G. Massimo, G. Zanardi, P. Colombo, Int. J. Pharm., 92, 23-28 (1993)

• A comparative study of the disintegrating efficiency of polysaccharides in a directly tablettable formulation, C. Duru, P. Colombo, D. Gaudy, G. Massimo, P. Santi, P.L. Catellani, P. Barthelemy, Pharm. Technol. Int., 4 (5), 15-23 (1992)
  
• The role of bond weakening by liquids in the disintegration of tablets, M. Luangtana-anan, P.L. Catellani, P. Colombo, R. Dinarvand, J.T. Fell, P. Santi, Eur. J. Pharm. Biopharm., 38 (5), 169-171 (1992)
• Centrifugal die filling system in a new rotary tablet machine, P.L. Catellani, P. Santi, E. Gasperini, S. CIceri, G. Dondi, P. Colombo, Int. J. Pharm., 88, 285-291 (1992)
• Permeation of piroxicam and piroxicam/ß-cyclodextrin inclusion compound through artificial membranes, R. Bettini, P. Santi, P.L. Catellani, G. Massimo, A. Bellotti, C. Barthélémy, A.-M. Guyot-Hermann, F. Trublin, P. Colombo, Eur. J. Pharm. Biopharm., 38 (6), 203-208 (1992)
  

• Partition and transport of verapamil and nicotine through artificial membranes, P. Santi, P.L. Catellani, P. Colombo, C. Ringard-Lefebvre, C. Barthélémy and A.M. Guyot-Hermann, Int. J. Pharm., 68, 43-49 (1991)
• Use of sucralfate humid gel in beauty masks formulation, D. Provasi, P. Colombo, G. Massimo, U. Conte, C. Caramella, P. Santi, Les Nouvelles Dermatologiques, 10 (1), 100-104 (1991)
• Release mechanism of piroxicam from ß-cyclodextrin inclusion compound, P. Colombo, P. Santi, D. Provasi, A. De Ascentiis, G. Massimo, P.L. Catellani, Acta Technologiae et Legis Medicamenti, 2 (1), 37-49 (1991)

• Piroxicam/ß-cyclodextrin inclusion compound ant its interaction with water, P.L. Catellani, P. Santi, M.G. Borazzo, A. Bellotti and P. Colombo, Minutes of 5th Intenational Symopsium on Cyclodextrins, Ed. D. Duchêne, Editions de Santé, Parigi (F) 445-449 (1990)

• Alprenolol.HCl compressed matrices: discontinuous barrier for zero-order release rate, P. Santi, P. L. Catellani, A. Cassarà and P. Colombo, Chimica Oggi, 7 (4), 21-24 (1989)